Concise synthesis of (-)-steviamine and analogues and their glycosidase inhibitory activities.
Org Biomol Chem
; 11(23): 3826-33, 2013 Jun 21.
Article
em En
| MEDLINE
| ID: mdl-23640519
ABSTRACT
A concise synthesis of (-)-steviamine is reported along with the synthesis of its analogues 10-nor-steviamine, 10-nor-ent-steviamine and 5-epi-ent-steviamine. These compounds were tested against twelve glycosidases (at 143 µg mL(-1) concentrations) and were found to have in general poor inhibitory activity against most enzymes. The 10-nor analogues however, showed 50-54% inhibition of α-L-rhamnosidase from Penicillium decumbens while one of these, 10-nor-steviamine, showed 51% inhibition of N-acetyl-ß-D-glucosaminidase (from Jack bean) at the same concentration (760 µM).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores Enzimáticos
/
Imino Açúcares
/
Indolizidinas
/
Glicosídeo Hidrolases
Idioma:
En
Revista:
Org Biomol Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Austrália