Simultaneous localization of calcitonin gene-related peptide and neurotensin in rat central amygdaloid nucleus.
Neurosci Lett
; 113(1): 1-6, 1990 May 18.
Article
em En
| MEDLINE
| ID: mdl-2366947
ABSTRACT
The distribution of calcitonin gene-related peptide (CGRP) and neurotensin (NT)-like immunoreactivities (LI) was studied in rat central amygdaloid nucleus (ACe) with immunocytochemical double staining. A dense network of CGRP- and NT-immunoreactive (IR) nerve fibers and some NT-positive neurons were found in the lateral and lateral capsular subnuclei. Light microscopically CGRP-immunoreactive nerve endings were in close contact to most of the NT-immunoreactive neurons. Under the electron microscope CGRP-positive terminals formed symmetric axo-somatic synapses with part of the NT-IR neurons. These results indicate that the NT- and CGRP-containing neuronal systems are in contact with each other in the ACe. Both peptides have marked effects on the circulatory system when administered intracerebrally. Thus the NT-IR neuronal system receiving synaptic input from CGRP-IR nerve terminals may mediate the cardiovascular effects of these two peptides.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neurotensina
/
Peptídeo Relacionado com Gene de Calcitonina
/
Tonsila do Cerebelo
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Finlândia