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Sulfated polysaccharide of Caesalpinia ferrea inhibits herpes simplex virus and poliovirus.
Lopes, Nayara; Faccin-Galhardi, Lígia Carla; Espada, Samantha Fernandes; Pacheco, Arcelina Cunha; Ricardo, Nágila Maria Pontes Silva; Linhares, Rosa Elisa Carvalho; Nozawa, Carlos.
Afiliação
  • Lopes N; Departamento de Microbiologia, CCB, Universidade Estadual de Londrina, CEP 86051-990, Londrina, Paraná, Brazil.
Int J Biol Macromol ; 60: 93-9, 2013 Sep.
Article em En | MEDLINE | ID: mdl-23707733
ABSTRACT
Herpes simplex virus (HSV) is one of the most regular human pathogens, being a public health problem, and causal agent of several diseases. Poliovirus (PV) is an enteric virus and about 1% of infected individuals develop paralytic poliomyelitis due to viral invasion of the central nervous system and destruction of motor neurons. This work evaluated the activity of a sulfated polysaccharide of Caesalpinia ferrea (SPLCf) in HSV and PV replication. The antiviral effect of SPLCf at varying concentrations was tested by plaque assay under several protocols, such as time-of-addition, adsorption and penetration inhibition and virucidal. Syntheses of viral protein and nucleic acid were also monitored by the immunofluorescence assay and PCR. The SPLCf inhibited virus adsorption and steps after penetration, and inhibited the synthesis of viral protein. Virucidal effect was also shown and nucleic acid synthesis was concurrent with positive results. Our findings suggested that the substance with low toxicity represent a potential viral inhibitor.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Polissacarídeos / Extratos Vegetais / Simplexvirus / Caesalpinia / Poliovirus Limite: Humans Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Polissacarídeos / Extratos Vegetais / Simplexvirus / Caesalpinia / Poliovirus Limite: Humans Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Brasil
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