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Central sleep apnea.
Javaheri, S; Dempsey, J A.
Afiliação
  • Javaheri S; University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. javaheri@snorenomore.com
Compr Physiol ; 3(1): 141-63, 2013 Jan.
Article em En | MEDLINE | ID: mdl-23720283
ABSTRACT
Neurophysiologically, central apnea is due to a temporary failure in the pontomedullary pacemaker generating breathing rhythm. As a polysomnographic finding, central apneas occur in many pathophysiological conditions. Depending on the cause or mechanism, central apneas may not be clinically significant, for example, those that occur normally at sleep onset. In contrast, central apneas occur in a number of disorders and result in pathophysiological consequences. Central apneas occur commonly in high-altitude sojourn, disrupt sleep, and cause desaturation. Central sleep apnea also occurs in number of disorders across all age groups and both genders. Common causes of central sleep apnea in adults are congestive heart failure and chronic use of opioids to treat pain. Under such circumstances, diagnosis and treatment of central sleep apnea may improve quality of life, morbidity, and perhaps mortality. The mechanisms of central sleep apnea have been best studied in congestive heart failure and hypoxic conditions when there is increased CO2 sensitivity below eupnea resulting in lowering eupneic PCO2 below apneic threshold causing cessation of breathing until the PCO2 rises above the apneic threshold when breathing resumes. In many other disorders, the mechanism of central sleep apnea (CSA) remains to be investigated.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apneia do Sono Tipo Central Tipo de estudo: Etiology_studies Aspecto: Patient_preference Limite: Animals / Humans Idioma: En Revista: Compr Physiol Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apneia do Sono Tipo Central Tipo de estudo: Etiology_studies Aspecto: Patient_preference Limite: Animals / Humans Idioma: En Revista: Compr Physiol Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Estados Unidos