STAT pathway in the regulation of zoledronic acid-induced apoptosis in chronic myeloid leukemia cells.
Biomed Pharmacother
; 67(6): 527-32, 2013 Jul.
Article
em En
| MEDLINE
| ID: mdl-23725755
ABSTRACT
In this study, we aimed to evaluate the cytotoxic and apoptotic effects of zoledronic acid on K562 chronic myeloid leukemia (CML) cells and to examine the roles of STAT genes on zoledronic acid-induced apoptosis. The results showed that zoledronic acid decreased proliferation, and induced apoptosis in K562 cells in a dose- and time-dependent manner. mRNA and protein levels of STAT3, -5A and -5B genes were significantly reduced in zoledronic acid-treated K562 cells. These data indicated that STAT inhibition by zoledronic acid may be therapeutic in CML patients following the confirmation with clinical studies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia Mielogênica Crônica BCR-ABL Positiva
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Apoptose
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Difosfonatos
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Fatores de Transcrição STAT
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Imidazóis
Limite:
Humans
Idioma:
En
Revista:
Biomed Pharmacother
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Turquia