Antiepileptic drug treatment: new drugs and new strategies.
Continuum (Minneap Minn)
; 19(3 Epilepsy): 643-55, 2013 Jun.
Article
em En
| MEDLINE
| ID: mdl-23739102
ABSTRACT
PURPOSE OF REVIEW Selection of the ideal antiepileptic drug (AED) for an individual patient can be a daunting process. Choice of treatment should be based on several factors, including but not limited to epilepsy classification, AED mechanism of action, AED side-effect profile, and drug interactions. Special consideration must be given to populations such as women, older adults, patients with other medical comorbidities, and patients who are newly diagnosed. RECENT FINDINGS:
Head-to-head trials between AEDs in newly diagnosed patients rarely demonstrate that one AED is more or less effective. The second-generation drugs, lamotrigine, topiramate, oxcarbazepine, zonisamide, and levetiracetam, have undergone head-to-head trials confirming similar efficacy and equal or better tolerability than standard drugs in focal epilepsy.SUMMARY:
A thoughtful approach to the AED selection process must factor in data from clinical AED trials as well as a variety of patient characteristics and confounding factors. When neurologists apply an individualized approach to AED drug selection for their patients, they can find an effective and well-tolerated drug for most patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Epilepsia
/
Anticonvulsivantes
Limite:
Adolescent
/
Aged
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Continuum (Minneap Minn)
Ano de publicação:
2013
Tipo de documento:
Article