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The duck genome and transcriptome provide insight into an avian influenza virus reservoir species.
Huang, Yinhua; Li, Yingrui; Burt, David W; Chen, Hualan; Zhang, Yong; Qian, Wubin; Kim, Heebal; Gan, Shangquan; Zhao, Yiqiang; Li, Jianwen; Yi, Kang; Feng, Huapeng; Zhu, Pengyang; Li, Bo; Liu, Qiuyue; Fairley, Suan; Magor, Katharine E; Du, Zhenlin; Hu, Xiaoxiang; Goodman, Laurie; Tafer, Hakim; Vignal, Alain; Lee, Taeheon; Kim, Kyu-Won; Sheng, Zheya; An, Yang; Searle, Steve; Herrero, Javier; Groenen, Martien A M; Crooijmans, Richard P M A; Faraut, Thomas; Cai, Qingle; Webster, Robert G; Aldridge, Jerry R; Warren, Wesley C; Bartschat, Sebastian; Kehr, Stephanie; Marz, Manja; Stadler, Peter F; Smith, Jacqueline; Kraus, Robert H S; Zhao, Yaofeng; Ren, Liming; Fei, Jing; Morisson, Mireille; Kaiser, Pete; Griffin, Darren K; Rao, Man; Pitel, Frederique; Wang, Jun.
Afiliação
  • Huang Y; State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China.
  • Li Y; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.
  • Burt DW; BGI-Shenzhen, Shenzhen, China.
  • Chen H; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.
  • Zhang Y; National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Harbin, China.
  • Qian W; BGI-Shenzhen, Shenzhen, China.
  • Kim H; BGI-Shenzhen, Shenzhen, China.
  • Gan S; Department of Agricultural Biotechnology, Seoul National University, Seoul, Korea.
  • Zhao Y; State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China.
  • Li J; State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China.
  • Yi K; BGI-Shenzhen, Shenzhen, China.
  • Feng H; BGI-Shenzhen, Shenzhen, China.
  • Zhu P; National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Harbin, China.
  • Li B; National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Harbin, China.
  • Liu Q; BGI-Shenzhen, Shenzhen, China.
  • Fairley S; State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China.
  • Magor KE; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
  • Du Z; Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.
  • Hu X; State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China.
  • Goodman L; State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China.
  • Tafer H; BGI-Shenzhen, Shenzhen, China.
  • Vignal A; Department of Computer Science, University of Leipzig, Leipzig, Germany.
  • Lee T; Department of Theoretical Chemistry, University of Vienna, Vienna, Austria.
  • Kim KW; Laboratoire de Génétique Cellulaire, Institut National de la Recherche Agronomique (INRA), Castanet-Tolosan, France.
  • Sheng Z; Department of Agricultural Biotechnology, Seoul National University, Seoul, Korea.
  • An Y; Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Korea.
  • Searle S; State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China.
  • Herrero J; State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China.
  • Groenen MAM; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
  • Crooijmans RPMA; European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
  • Faraut T; Animal Breeding and Genomics Centre, Wageningen University, Wageningen, The Netherlands.
  • Cai Q; Animal Breeding and Genomics Centre, Wageningen University, Wageningen, The Netherlands.
  • Webster RG; Laboratoire de Génétique Cellulaire, Institut National de la Recherche Agronomique (INRA), Castanet-Tolosan, France.
  • Aldridge JR; BGI-Shenzhen, Shenzhen, China.
  • Warren WC; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Bartschat S; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
  • Kehr S; The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Marz M; Department of Computer Science, University of Leipzig, Leipzig, Germany.
  • Stadler PF; Department of Computer Science, University of Leipzig, Leipzig, Germany.
  • Smith J; Department of Computer Science, University of Leipzig, Leipzig, Germany.
  • Kraus RHS; Department of Computer Science, University of Leipzig, Leipzig, Germany.
  • Zhao Y; Department of Theoretical Chemistry, University of Vienna, Vienna, Austria.
  • Ren L; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.
  • Fei J; Resource Ecology Group, Wageningen University, Wageningen, The Netherlands.
  • Morisson M; Conservation Genetics Group, Senckenberg Research Institute and Natural History Museum, Gelnhausen, Germany.
  • Kaiser P; State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China.
  • Griffin DK; State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China.
  • Rao M; State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China.
  • Pitel F; Laboratoire de Génétique Cellulaire, Institut National de la Recherche Agronomique (INRA), Castanet-Tolosan, France.
  • Wang J; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.
Nat Genet ; 45(7): 776-783, 2013 Jul.
Article em En | MEDLINE | ID: mdl-23749191
The duck (Anas platyrhynchos) is one of the principal natural hosts of influenza A viruses. We present the duck genome sequence and perform deep transcriptome analyses to investigate immune-related genes. Our data indicate that the duck possesses a contractive immune gene repertoire, as in chicken and zebra finch, and this repertoire has been shaped through lineage-specific duplications. We identify genes that are responsive to influenza A viruses using the lung transcriptomes of control ducks and ones that were infected with either a highly pathogenic (A/duck/Hubei/49/05) or a weakly pathogenic (A/goose/Hubei/65/05) H5N1 virus. Further, we show how the duck's defense mechanisms against influenza infection have been optimized through the diversification of its ß-defensin and butyrophilin-like repertoires. These analyses, in combination with the genomic and transcriptomic data, provide a resource for characterizing the interaction between host and influenza viruses.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Reservatórios de Doenças / Genoma / Patos / Transcriptoma / Influenza Aviária Limite: Animals Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Reservatórios de Doenças / Genoma / Patos / Transcriptoma / Influenza Aviária Limite: Animals Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2013 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos