Controlled systemic release of therapeutic peptides from PEGylated prodrugs by serum proteases.
Angew Chem Int Ed Engl
; 52(29): 7597-9, 2013 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-23766125
ABSTRACT
A novel concept to release peptidic drugs systemically by serum proteases from a PEGylated precursor makes it possible to tune release kinetics to fit the medical needs. Drug release depends on the size of the PEG polymer and the sequence and length of the peptide linker. The antimicrobial activities of the prodrugs were even better than those of the free peptides, whereas direct PEGylation abolished the peptide activity.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeo Hidrolases
/
Polietilenoglicóis
/
Pró-Fármacos
/
Peptídeos Catiônicos Antimicrobianos
Limite:
Animals
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Alemanha