Parkinson disease loci in the mid-western Amish.
Hum Genet
; 132(11): 1213-21, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-23793441
ABSTRACT
Previous evidence has shown that Parkinson disease (PD) has a heritable component, but only a small proportion of the total genetic contribution to PD has been identified. Genetic heterogeneity complicates the verification of proposed PD genes and the identification of new PD susceptibility genes. Our approach to overcome the problem of heterogeneity is to study a population isolate, the mid-western Amish communities of Indiana and Ohio. We performed genome-wide association and linkage analyses on 798 individuals (31 with PD), who are part of a 4,998 member pedigree. Through these analyses, we identified a region on chromosome 5q31.3 that shows evidence of association (p value < 1 × 10(-4)) and linkage (multipoint HLOD = 3.77). We also found further evidence of linkage on chromosomes 6 and 10 (multipoint HLOD 4.02 and 4.35 respectively). These data suggest that locus heterogeneity, even within the Amish, may be more extensive than previously appreciated.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Loci Gênicos
/
Amish
Limite:
Humans
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Hum Genet
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos