Acute toxicity of some synthetic cyanogens in rats: time-dependent cyanide generation and cytochrome oxidase inhibition in soft tissues after sub-lethal oral intoxication.
Food Chem Toxicol
; 59: 595-609, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-23831730
Cyanogens include complex nitrile-containing compounds that can generate free cyanide of toxicological significance. Acute toxicity, time-dependent cyanide generation and cytochrome oxidase (CYTOX) inhibition in soft tissues, and urinary thiocyanate levels were measured after acute cyanogen intoxication in rats. Order of cyanogens in terms of LD50 was: malononitrile (MCN)>propionitrile (PCN)≈sodium nitroprusside (SNP)>acrylonitrile (ACN)>succinonitrile (SCN)>acetonitrile (ATCN) for oral, and SNP>MCN>ACN>PCN>SCN>ATCN for intraperitoneal and subcutaneous routes. MCN was most toxic by oral (LD50=66.4 mg/kg) and SNP by intraperitoneal (LD50=16.7 mg/kg) and subcutaneous (LD50=11.9 mg/kg) routes. Minimum survival time (25 min) was recorded after 4.0 LD50 ATCN. Order of cyanogens (0.75 LD50; oral) on the basis of maximum blood cyanide and time of peak cyanide generation were: ATCN>SNP>SCN>PCN>MCN>ACN, and MCN (30 min)
AssuntosPalavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vasodilatadores
/
Nitroprussiato
/
Complexo IV da Cadeia de Transporte de Elétrons
/
Cianetos
/
Inibidores Enzimáticos
/
Nitrilas
Limite:
Animals
Idioma:
En
Revista:
Food Chem Toxicol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Índia
País de publicação:
Reino Unido
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vasodilatadores
/
Nitroprussiato
/
Complexo IV da Cadeia de Transporte de Elétrons
/
Cianetos
/
Inibidores Enzimáticos
/
Nitrilas
Limite:
Animals
Idioma:
En
Revista:
Food Chem Toxicol
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Índia
País de publicação:
Reino Unido