Pharmacodynamics and pharmacokinetics of AHR-11748, a new antiepileptic agent, in rodents.
Epilepsy Res
; 5(3): 185-91, 1990 Apr.
Article
em En
| MEDLINE
| ID: mdl-2384074
ABSTRACT
AHR-11748, the desmethyl metabolite of fluzinamide (an effective antiepileptic), was active in preventing maximal seizures induced in mice or rats by electroshock and threshold seizures induced in mice by Metrazol, bicuculline, and picrotoxin. The compound showed a profile of anticonvulsant activity similar to those of phenobarbital and valproic acid and different from those of phenytoin and ethosuximide. ED50s were less than those of valproic acid, but greater than those of phenobarbital. Analysis of plasma and whole brain homogenates of mice indicated that AHR-11748 has an apparent terminal half-life (t1/2, beta) of 1.0 h. The brainplasma ratio of AHR-11748 was 3.41 from 0.5 h to 6 h.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Azetidinas
/
Azetinas
/
Epilepsia
/
Anticonvulsivantes
Limite:
Animals
Idioma:
En
Revista:
Epilepsy Res
Assunto da revista:
CEREBRO
/
NEUROLOGIA
Ano de publicação:
1990
Tipo de documento:
Article