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Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase of Trypanosoma brucei.
Lu, Jun; Vodnala, Suman K; Gustavsson, Anna-Lena; Gustafsson, Tomas N; Sjöberg, Birger; Johansson, Henrik A; Kumar, Sangit; Tjernberg, Agneta; Engman, Lars; Rottenberg, Martin E; Holmgren, Arne.
Afiliação
  • Lu J; Division of Biochemistry, Department of Medical Biochemistry and Biophysics.
  • Vodnala SK; Department of Microbiology, Tumor and Cell Biology.
  • Gustavsson AL; Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine, Karolinska Institutet, SE-17177 Stockholm, Sweden.
  • Gustafsson TN; Division of Biochemistry, Department of Medical Biochemistry and Biophysics.
  • Sjöberg B; Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine, Karolinska Institutet, SE-17177 Stockholm, Sweden.
  • Johansson HA; Division of Biochemistry, Department of Medical Biochemistry and Biophysics; Department of Chemistry-BMC, Uppsala University, SE-751 23 Uppsala, Sweden.
  • Kumar S; Chemistry Department, IISER Bhopal, MP, India.
  • Tjernberg A; Swedish Orphan Biovitrum AB, SE-112 76 Stockholm, Sweden.
  • Engman L; Department of Chemistry-BMC, Uppsala University, SE-751 23 Uppsala, Sweden.
  • Rottenberg ME; Department of Microbiology, Tumor and Cell Biology. Electronic address: Martin.Rottenberg@ki.se.
  • Holmgren A; Division of Biochemistry, Department of Medical Biochemistry and Biophysics. Electronic address: Arne.Holmgren@ki.se.
J Biol Chem ; 288(38): 27456-27468, 2013 Sep 20.
Article em En | MEDLINE | ID: mdl-23900839
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiazóis / Tripanossomicidas / Trypanosoma brucei brucei / Tripanossomíase Africana / Proteínas de Protozoários / NADH NADPH Oxirredutases Limite: Animals Idioma: En Revista: J Biol Chem Ano de publicação: 2013 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiazóis / Tripanossomicidas / Trypanosoma brucei brucei / Tripanossomíase Africana / Proteínas de Protozoários / NADH NADPH Oxirredutases Limite: Animals Idioma: En Revista: J Biol Chem Ano de publicação: 2013 Tipo de documento: Article País de publicação: Estados Unidos