A biomarker of oxidative stress as a nontraditional risk factor in obese subjects.
Biomark Med
; 7(4): 633-9, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-23905900
ABSTRACT
BACKGROUND:
Oxidative stress has been postulated as an additive factor linking obesity to cardiovascular disease. MATERIALS &METHODS:
Derivatives of reactive oxygen species metabolites (d-ROMs) were measured in 136 obese (42 males, 94 females; mean age 47 ± 12 years; BMI 36 ± 5 kg/m(2)) and in 306 over- and normal-weight subjects (112 males, 194 females; age 47 ± 12 years; BMI 24 ± 3 kg/m(2)).RESULTS:
d-ROMs levels were higher in obese than in over- and normal-weight subjects (395 ± 104 vs 362 ± 102 and 351 ± 84 arbitrary units (AU); p < 0.001), in women than males (390 ± 104 vs 327 ± 68 AU; p < 0.001), in subjects with than those without hypertension (390 ± 103 vs 360 ± 95 AU; p < 0.01) and in smokers than former and nonsmokers (380 ± 97 vs 358 ± 97 AU; p < 0.05). A positive correlation was found between d-ROMs and BMI (r = 0.25; p < 0.001) and age (r = 0.13; p < 0.01). Levels of d-ROM (>75th percentile 420 AU) remained as an independent obesity predictor (odds ratio 2.5; p < 0.001) in women. Continuous variables are reported as mean ± standard deviation.CONCLUSION:
d-ROMs are a powerful obesity predictor, and could represent a reliable tool in obesity and cardiovascular risk evaluation, especially in women.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estresse Oxidativo
/
Obesidade
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Biomark Med
Assunto da revista:
BIOQUIMICA
/
MEDICINA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Itália