Neovascularization in the carotid atherosclerotic plaque is not associated with inflammatory cell aggregation.
Chin Med J (Engl)
; 126(16): 3073-8, 2013 Aug.
Article
em En
| MEDLINE
| ID: mdl-23981615
ABSTRACT
BACKGROUND:
Monocytes and macrophages in atherosclerotic plaque lead to plaque instability. The aim of the study was to determine if plaque neovascularization led to inflammation.METHODS:
Patients were consecutively enrolled if their carotid intimal media thickness was > 2 mm, as revealed by duplex ultrasound. The patients then underwent dynamic contrast enhanced magnetic resonance imaging (DCE MRI) and fluorine-18 fluorodeoxyglucose ((18)F-FDG) positron emission tomography combined with computed tomography (PET CT). A target to background ratio (TBR) of ≥ 1.25 or < 1.25 served as the cutoff point for the presence and absence of inflammation, respectively.RESULTS:
Twenty-six patients underwent bilateral carotid DCE MRI and 24 patients also underwent PET CT. One hundred and fifty-five plaques were evaluated by both DCE MRI and PET CT. There was no significant difference in plaque morphology between the TBR ≥ 1.25 (n = 61) and TBR < 1.25 (n = 94) groups. No significant differences were found in plasma volume and transfer constant between the TBR ≥ 1.25 and TBR < 1.25 groups.CONCLUSION:
Our study did not find a significant correlation between plaque neovascularization and the aggregation of inflammatory cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças das Artérias Carótidas
/
Placa Aterosclerótica
/
Inflamação
/
Macrófagos
/
Neovascularização Patológica
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Chin Med J (Engl)
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
China