Antitumor, antioxidant and antimicrobial studies of substituted pyridylguanidines.
Molecules
; 18(9): 10378-96, 2013 Aug 27.
Article
em En
| MEDLINE
| ID: mdl-23985956
ABSTRACT
A series of N-pivaloyl-N'-(alkyl/aryl)-N''-pyridylguanidine of general formula C4H9CONHC(NR¹R²)NPy have been synthesized and characterized using elemental analysis, FT-IR, multinuclear NMR spectroscopy, and in the case of compounds 7 and 11, by single crystal X-ray diffraction (XRD). The synthesized guanidines were tested for antitumor activities against potato tumor, and showed excellent inhibition against Agrobacterium tumefaciens (AT10)-induced tumor. The antioxidant and antimicrobial activities of these new compounds against various bacterial and fungal strains were also investigated.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Sequestradores de Radicais Livres
/
Guanidinas
/
Antibacterianos
/
Antifúngicos
/
Antineoplásicos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Molecules
Assunto da revista:
BIOLOGIA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Paquistão