Use of conivaptan for management of hyponatremia following surgery for Cushing's disease.
Clin Neurol Neurosurg
; 115(11): 2358-61, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-24041963
ABSTRACT
BACKGROUND:
Hyponatremia due to syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a common osmoregulatory complication following surgery for Cushing's disease. Conventional management includes water restriction and sodium repletion, however this regimen does not address the underlying pathophysiology of excessive vasopressin production. Vaptans are arginine vasopressin receptor antagonists shown to be effective in correcting water excess in other disease states of euvolemic and hypervolemic hyponatremia. The use of these agents has not been reported in Cushing's patients.METHODS:
We retrospectively studied Cushing's patients at our institution with post-surgical hyponatremia (Na<130mEq/L) treated with and without conivaptan between 2005 and 2011. We report rates of serum sodium normalization and compare length-of-stay (LOS) between the groups.RESULTS:
Hyponatremia developed in six of 98 patients (6.1%) undergoing resection of ACTH-positive pituitary adenomas. Three patients received conivaptan and fluid restriction±sodium supplementation, and three received conventional therapy alone. The rate of serum sodium normalization with conivaptan was 5.8±2.3mEq/L/20mg IV bolus given every 24h. All patients receiving conivaptan were discharged with normal serum sodium values and no instances of rapid overcorrection occurred. A trend toward longer LOS occurred in patients treated with conivaptan (4.6±0.3 days, mean±SE) versus conventional therapy alone (1.6±0.3 days).CONCLUSIONS:
Conivaptan is a potentially useful treatment option for hyponatremia in the setting of Cushing's disease patients after pituitary surgery.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzazepinas
/
Síndrome de Cushing
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Antagonistas dos Receptores de Hormônios Antidiuréticos
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Hiponatremia
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Síndrome de Secreção Inadequada de HAD
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Clin Neurol Neurosurg
Ano de publicação:
2013
Tipo de documento:
Article