Can calcium dobesilate be used safely for peripheral microvasculopathies that require neoangiogenesis?
Med Sci Monit Basic Res
; 19: 253-7, 2013 Sep 27.
Article
em En
| MEDLINE
| ID: mdl-24072135
ABSTRACT
BACKGROUND:
Calcium dobesilate (CaD) is a member of the synthetic veno-active drug family. Only a small number of reports are available that describe the micro-angiogenic effects of CaD in the current literature. MATERIAL ANDMETHODS:
The antiangiogenic potential of CaD was compared with bevacizumab (Bb), which is a potent angiogenesis inhibitor, in a chick chorioallantoic membrane model. Four different concentrations (10-7, 10-6, 10-5, and 10-4 M) of drug pellet were prepared for each drug. Changes in vessel formation were scored and compared for each drug according to the previous literature.RESULTS:
The antiangiogenic behavior of CaD was lower than Bb, despite the significant dose-dependent manner of escalation. The anti-angiogenic scores of CaD were determined as 0.20, 0.47, 0.66, 1.0 in 10-7, 10-6, 10-5, and 10-4 M concentrations, respectively (average score >0.5 was significant).CONCLUSIONS:
According to the data obtained, this agent should be used carefully for cases in which angiogenesis plays an important role in healing.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dobesilato de Cálcio
/
Doenças Vasculares Periféricas
/
Microvasos
/
Neovascularização Patológica
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Med Sci Monit Basic Res
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Turquia