Expanding dynamic kinetic protocols: transaminase-catalyzed synthesis of α-substituted ß-amino ester derivatives.

ABSTRACT

Several α-alkylated ß-amino esters have been obtained via DKR processes employing a kit of transaminases and isopropylamine as an amino donor in aqueous medium under mild conditions. Thus, while acyclic α-alkyl-ß-keto esters afforded excellent conversions and enantioselectivities, although usually low diastereoselectivities, using more constrained cyclic ß-keto esters high to excellent inductions were obtained.