Genes on different chromosomes influence the antibody response to bacterial antigens.
Immunogenetics
; 22(3): 269-76, 1985.
Article
em En
| MEDLINE
| ID: mdl-2412957
ABSTRACT
B6.C congenic strains of mice, possessing histocompatibility (H) alleles from high responding BALB/cBy (C) mice on the genetic background of low responding C57BL/6By (B6) mice, were assayed for their ability to make an antibody response to Type III pneumococcal polysaccharide (SSS-III) and the alpha(1----3) epitope of bacterial (Leuconostoc) dextran B-1355. The results affirmed that the antibody response to SSS-III is multigenic and that genes making a positive contribution to responsiveness are located on different chromosomes, i.e., chromosomes 1, 3, 4, 5, and 9. At least one other gene also influences responsiveness to SSS-III; it is linked to the H-17 locus, which has not yet been assigned to a specific chromosome. Genes on chromosomes 1, 4, and 5 influence the magnitude of the antibody response to dextran B-1355. Some of these genes may be antigen-specific in their mode of action; however, others may not since they appear to exert a positive influence on the antibody response to both SSS-III and dextran B-1355.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos Bacterianos
/
Genes MHC da Classe II
/
Anticorpos Antibacterianos
/
Antígenos de Bactérias
Limite:
Animals
Idioma:
En
Revista:
Immunogenetics
Ano de publicação:
1985
Tipo de documento:
Article