Interferon-mediated regulation of myc and Ki-ras oncogene expression in long-term-treated murine viral transformed cells.
J Interferon Res
; 5(4): 613-9, 1985.
Article
em En
| MEDLINE
| ID: mdl-2418130
ABSTRACT
Long-term treatment of a murine retroviral-transformed cell line (Ki-Balb) with 50 units/ml of interferon (IFN) resulted in a morphological reversion. The effects of IFN on myc and Ki-ras oncogene expression were examined after 6 months of treatment. mRNA dot and Northern blots hybridization analysis reveal that the expression of c-myc at the RNA level decreases by about fourfold. This reduction in the c-myc mRNA appears to be selective since in the same cells v-Ki-ras and an endogenous retroviral gene, intracisternal A particles (IAP), are increased four- and threefold, respectively. No significant inhibition of cellular growth and cell-cycle distribution was observed in IFN-Ki-Balb-treated cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oncogenes
/
Regulação da Expressão Gênica
/
Interferons
Limite:
Animals
Idioma:
En
Revista:
J Interferon Res
Ano de publicação:
1985
Tipo de documento:
Article