Pepsin levels and oxidative stress markers in exhaled breath condensate of patients with gastroesophageal reflux disease.
J Pediatr Surg
; 48(11): 2247-50, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-24210194
ABSTRACT
AIM:
To evaluate the pepsin and oxidative stress markers in exhaled breath condensate (EBC) in patients with gastroesophageal reflux disease (GERD). PATIENTS ANDMETHOD:
Patients with a presumptive diagnosis of GERD with recurrent respiratory and gastrointestinal problems aged between 2 and 14 years were included in the study. All patients underwent pH monitoring. Patients with a reflux index (RI) ≥4 were assessed as the reflux group, and those with an RO <4 were assessed as the non-reflux group. Pepsin levels and oxidative stress markers [NO metabolites (NOX) and total sulphydrile (TSH) levels] were measured in the EBC.RESULTS:
There were 24 patients in the reflux group [RI 17.6 (6.6-46.4)] [median, interquartile range] and 23 in the non-reflux group [RI 0.8 (0.5-1.9) (p<0.001). Pepsin levels in the EBC were below the level of detection. The median levels of NOx in the EBC of children with reflux [13.7 µmol/L (7.3-24.5)] were lower in than non-reflux group [21.0 µmol/L (14.0-25.2)] (p=0.034). There was a negative correlation between reflux index and NOX levels in EBC (rs -0.331, p=0.023). In contrast, there was no difference in TSH levels between the reflux and non-reflux groups [37.4 µmol/L (30.2-44.6) vs 40.1 µmol/L (37.4-44.9), respectively, (p>0.05)].CONCLUSION:
Decreased levels of NOX in patients with GER disease suggest increased oxidative stress in airways of these patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Testes Respiratórios
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Refluxo Gastroesofágico
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Pepsina A
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Estresse Oxidativo
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Revista:
J Pediatr Surg
Ano de publicação:
2013
Tipo de documento:
Article
País de publicação:
EEUU
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ESTADOS UNIDOS
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ESTADOS UNIDOS DA AMERICA
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EUA
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UNITED STATES
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UNITED STATES OF AMERICA
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US
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USA