Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands.
Bioorg Med Chem Lett
; 23(24): 6920-6922, 2013 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-24211020
ABSTRACT
Selective σ2 ligands continue to be an active target for medications to attenuate the effects of psychostimulants. In the course of our studies to determine the optimal substituents in the σ2-selective phenyl piperazines analogues with reduced activity at other neurotransmitter systems, we discovered that 1-(3-chlorophenyl)-4-phenethylpiperazine actually had preferentially increased affinity for dopamine transporters (DAT), yielding a highly selective DAT ligand.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Proteínas da Membrana Plasmática de Transporte de Dopamina
/
Ligantes
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2013
Tipo de documento:
Article
País de afiliação:
Estados Unidos