3-Deazauridine (NSC 126849): an interesting modulator of biochemical response.
Invest New Drugs
; 4(1): 67-84, 1986.
Article
em En
| MEDLINE
| ID: mdl-2422137
ABSTRACT
3-Deazauridine (NSC 126849) is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase which is considered to be the primary mode of action of this nucleoside analog. Despite a paucity of clinical attention given to this drug as a single agent, it has generated much enthusiasm as a biological response modulator because of its synergistic effect with a number of antitumor agents including Cytosine Arabinoside, 5-aza-2'-deoxycytidine, 5-azacytidine, thymidine and D-galactosamine, although only the cytosine arabinoside/3-Deazauridine combination has been explored clinically. In this paper, the current status of the drug and future perspectives will be discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Uridina
/
3-Desazauridina
/
Antineoplásicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Invest New Drugs
Ano de publicação:
1986
Tipo de documento:
Article
País de publicação:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA