Novel arylazoarylmethane as potential inhibitor of macrophage migration inhibitory factor.
Arch Pharm (Weinheim)
; 347(2): 104-7, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-24243226
ABSTRACT
Macrophage migration inhibitory factor (MIF), a cytokine involved in the pathogenesis of sepsis, diabetes, asthma, arthritis, and cancer, has an enzymatic active site that has proven to be an effective target for small molecule-based inhibitors. Herein, we describe the synthesis of a novel arylazoarylmethane compound (3) from a known arylhydrazone MIF inhibitor (2). This new compound has improved stability and in vivo biological activity.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores Inibidores da Migração de Macrófagos
/
Inibidores Enzimáticos
/
Hidrazonas
/
Anti-Inflamatórios
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Arch Pharm (Weinheim)
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos