[Serum proteomic analysis of cicatricial airway stenosis].

ABSTRACT

OBJECTIVE: To establish serum protein fingerprint profile in patients with cicatricial airway stenosis and compared with healthy control. METHODS: Serum samples of 17 cicatricial airway stenosis patients and 17 healthy persons were analyzed by SELDI-TOF-MS to select the differently expressed proteins through Biomarker Wizard software. RESULTS: Compared with healthy control, 49 protein biomarkers were identified. Among them, 25 proteins were up-regulated, 24 proteins were down-regulated. These proteins were confirmed by searching database. CONCLUSIONS: There are obvious differentially expressed proteins in patients with cicatricial airway stenosis and controls, which may related with the development of airway scar.