Gq-mER signaling has opposite effects on hypothalamic orexigenic and anorexigenic neurons.
Steroids
; 81: 31-5, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-24269736
ABSTRACT
Two populations of cells within the hypothalamus exert opposite actions on food intake proopiomelanocortin (POMC) neurons decrease it, while neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons increase it. 17ß-Estradiol (E2) is a potent anorexigenic hormone that exerts both genomic and non-genomic, rapid actions on these metabolic neurons. This review focuses on the rapid membrane effects of E2 in both POMC and NPY/AgRP neurons and how these combined effects mediate the anorexigenic effects of this steroid.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Subunidades alfa Gq-G11 de Proteínas de Ligação ao GTP
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Ingestão de Alimentos
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Estradiol
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Hipotálamo
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Neurônios
Limite:
Animals
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Humans
Idioma:
En
Revista:
Steroids
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos