Amino acid losses during sustained low efficiency dialysis in critically ill patients with acute kidney injury.
Clin Nephrol
; 81(2): 93-9, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-24290407
ABSTRACT
OBJECTIVE:
Sustained low efficiency dialysis (SLED) involves the use of standard dialysis machines for prolonged intermittent renal replacement therapy in critically ill patients. In this study we aimed to quantify dialysate amino acid (AA) and albumin losses in 5 patients who underwent successful SLED treatment.DESIGN:
This was a prospective observational study.SETTING:
The study was performed in a general intensive care unit.SUBJECTS:
The study was performed in critically ill patients with acute kidney injury undergoing SLED using low-flux hemodialyzers. INTERVENTION We performed total dialysate collection and measured dialysate AA profiles by reverse phase high-pressure liquid chromatography using an automated AA analyser. MAIN OUTCOMEMEASURE:
Individual and total amino acid losses.RESULTS:
Albumin was undetectable in dialysate. The median (mean ± SD) total amino acid loss was 15.7 (23.4 ± 19.2) g/treatment, or 122.1 (180.6 ± 148.5) mmol/treatment. Two patients were receiving intravenous nutrition. One patient had severe hepatic failure with encephalopathy, and had high dialysate AA levels with a total loss of 57 g/treatment.CONCLUSIONS:
During SLED with low-flux hemodialyzers, albumin losses are negligible but AA losses to dialysate are comparable to those during continuous renal replacement therapy. Patients' nutritional protein prescriptions should be augmented to account for this.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Soluções para Diálise
/
Diálise Renal
/
Injúria Renal Aguda
/
Aminoácidos
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
Limite:
Aged
/
Aged80
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Nephrol
Ano de publicação:
2014
Tipo de documento:
Article