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The inheritance of extra-hepatic portosystemic shunts and elevated bile acid concentrations in Maltese dogs.
O'Leary, C A; Parslow, A; Malik, R; Hunt, G B; Hurford, R I; Tisdall, P L C; Duffy, D L.
Afiliação
  • O'Leary CA; School of Veterinary Science, The University of Queensland, Brisbane, 4072, Australia.
J Small Anim Pract ; 55(1): 14-21, 2014 Jan.
Article em En | MEDLINE | ID: mdl-24299127
ABSTRACT

OBJECTIVES:

To determine the heritability of extra-hepatic portosystemic shunts and elevated post-prandial serum bile acid concentrations in Maltese dogs. MATERIALS AND

METHODS:

Maltese dogs were recruited and investigated by a variable combination of procedures including dynamic bile acid testing, rectal ammonia tolerance testing, ultrasonography, portal venography, surgical inspection or necropsy. In addition, nine test matings were carried out between affected and affected dogs, and affected and unaffected dogs.

RESULTS:

In 135 variably related Maltese, shunt status could be confirmed in 113, including 19 with an extra-hepatic portosystemic shunt (17 confirmed at surgery, 2 at necropsy). Rectal ammonia tolerance testing results and post-prandial serum bile acid concentrations were retrievable for 50 and 88 dogs, respectively. Pedigree information was available for these 135 and an additional 164 related dogs. Two consecutive test matings were carried out between two affected animals (whose shunts had been attenuated), with 2 of 8 (25%) of offspring having an extra-hepatic portosystemic shunt. Six test matings were carried out between an affected and an unaffected animal, with 2 of 22 (9%) offspring affected. Heritability of extra-hepatic portosystemic shunt was 0·61 calculated using variance components analysis [95% confidence interval (CI) 0·14 to 1·0, P=0·001]. The best fitting model from segregation analysis was a common, partially penetrant, recessive model (allele frequency 0·34, penetrance 0·99, CI 0·09 to 1·0). The heritability of elevated post-prandial serum bile acid (and thus likely portal vein hypoplasia) was 0·81 (CI 0·43 to 1·0, P=0·2) after logarithmic transformation of post-prandial serum bile acid concentrations. CLINICAL

SIGNIFICANCE:

There is strong support for extra-hepatic portosystemic shunts and elevated post-prandial serum bile acid concentrations both being inherited conditions in Maltese.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Veia Porta / Ácidos e Sais Biliares / Doenças do Cão Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Small Anim Pract Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Austrália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Veia Porta / Ácidos e Sais Biliares / Doenças do Cão Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Small Anim Pract Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Austrália