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[Therapeutic effects of gegen qinlian decoction and its mechanism of action on type 2 diabetic rats].
Li, Ying-meng; Fan, Xue-mei; Wang, Yi-ming; Liang, Qiong-lin; Luo, Guo-an.
Afiliação
  • Li YM; School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
  • Fan XM; Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China.
  • Wang YM; School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
  • Liang QL; Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China.
  • Luo GA; School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
Yao Xue Xue Bao ; 48(9): 1415-21, 2013 Sep.
Article em Zh | MEDLINE | ID: mdl-24358775
ABSTRACT
The objective of this study is to fully investigate the therapeutic effect and mechanisms of action of Gegen Qinlian decoction (GD) on type 2 diabetes mellitus (type 2 DM). A rat model of type 2 DM was established with the combination of high-fat diet and multiple low doses of streptozotocin (STZ). Biochemical indicators related to glucose metabolism disorders, insulin resistance, oxidative stress were observed. The type 2 DM rats were administrated with GD for 80 days, the above-mentioned indexes were detected. The results indicated that the hepatic glycogen synthesis level was promoted, fasting blood glucose level and fasting blood insulin level were significantly reduced, insulin sensitivity index was significantly improved; the level of superoxide dismutase (SOD) was increased and the level of malondialdehyde (MDA) was reduced; pathologic morphology of pancreas and kidney was ameliorated in the GD group. It was indicated that the therapeutic mechanisms of action of GD on type 2 DM might be related to its effect of ameliorating glucose metabolism disorders, relieving insulin resistance, increasing the tissues' sensitivity to insulin, improving the antioxidative ability of living system, GD has therapeutic effect on type 2 DM and protective effects against damaged pancreatic function.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Diabetes Mellitus Tipo 2 / Hipoglicemiantes / Fitoterapia Limite: Animals Idioma: Zh Revista: Yao Xue Xue Bao Ano de publicação: 2013 Tipo de documento: Article País de afiliação: China
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Diabetes Mellitus Tipo 2 / Hipoglicemiantes / Fitoterapia Limite: Animals Idioma: Zh Revista: Yao Xue Xue Bao Ano de publicação: 2013 Tipo de documento: Article País de afiliação: China