Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility.
Chem Commun (Camb)
; 50(14): 1688-90, 2014 Feb 18.
Article
em En
| MEDLINE
| ID: mdl-24394756
Ionic liquids (ILs) have been exploited to improve the absorption of poorly water-soluble drugs. Custom-made ILs solubilized very high quantities of the poorly water-soluble drugs, danazol and itraconazole, and maintained drug solubilization under simulated gastro-intestinal conditions. A danazol-containing self-emulsifying IL formulation gave rise to 4.3-fold higher exposure than the crystalline drug and prolonged exposure compared with a lipid formulation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Portadores de Fármacos
/
Líquidos Iônicos
Limite:
Animals
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Austrália
País de publicação:
Reino Unido