Cortical glutamate levels decrease in a non-human primate model of dopamine deficiency.
Brain Res
; 1552: 34-40, 2014 Mar 13.
Article
em En
| MEDLINE
| ID: mdl-24398457
ABSTRACT
While Parkinson's disease is the result of dopaminergic dysfunction of the nigrostriatal system, the clinical manifestations of Parkinson's disease are brought about by alterations in multiple neural components, including cortical areas. We examined how 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration affected extracellular cortical glutamate levels by comparing glutamate levels in normal and MPTP-lesioned nonhuman primates (Macaca mulatta). Extracellular glutamate levels were measured using glutamate microelectrode biosensors. Unilateral MPTP-administration rendered the animals with hemiparkinsonian symptoms, including dopaminergic deficiencies in the substantia nigra and the premotor and motor cortices, and with statistically significant decreases in basal glutamate levels in the primary motor cortex on the side ipsilateral to the MPTP-lesion. These results suggest that the functional changes of the glutamatergic system, especially in the motor cortex, in models of Parkinson's disease could provide important insights into the mechanisms of this disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Substância Negra
/
Dopamina
/
Ácido Glutâmico
/
Transtornos Parkinsonianos
/
Macaca mulatta
/
Córtex Motor
Limite:
Animals
Idioma:
En
Revista:
Brain Res
Ano de publicação:
2014
Tipo de documento:
Article