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Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials.
Franciosi, Lui G; Diamant, Zuzana; Banner, Katharine H; Zuiker, Rob; Morelli, Nicoletta; Kamerling, Ingrid M C; de Kam, Marieke L; Burggraaf, Jacobus; Cohen, Adam F; Cazzola, Mario; Calzetta, Luigino; Singh, Dave; Spina, Domenico; Walker, Michael J A; Page, Clive P.
Afiliação
  • Franciosi LG; Verona Pharma, London, UK; Department of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
  • Diamant Z; Centre for Human Drug Research, Leiden, Netherlands; Skane University, Department of Respiratory Diseases and Allergology, Lund, Sweden; University Medical Centre Groningen, Department of General Practice, Groningen, Netherlands.
  • Banner KH; Verona Pharma, London, UK.
  • Zuiker R; Centre for Human Drug Research, Leiden, Netherlands.
  • Morelli N; Centre for Human Drug Research, Leiden, Netherlands.
  • Kamerling IM; Centre for Human Drug Research, Leiden, Netherlands.
  • de Kam ML; Centre for Human Drug Research, Leiden, Netherlands.
  • Burggraaf J; Centre for Human Drug Research, Leiden, Netherlands.
  • Cohen AF; Centre for Human Drug Research, Leiden, Netherlands.
  • Cazzola M; Unit of Respiratory Clinical Pharmacology, Department of System Medicine, University of Rome "Tor Vergata", Rome, Italy.
  • Calzetta L; Department of Respiratory Rehabilitation, San Raffaele Pisana Hospital, IRCCS, Rome, Italy.
  • Singh D; University of Manchester, Medicines Evaluation Unit, University Hospital of South Manchester Foundations Trust, Manchester, UK.
  • Spina D; Verona Pharma, London, UK; Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King's College London, London, UK.
  • Walker MJ; Verona Pharma, London, UK; Department of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
  • Page CP; Verona Pharma, London, UK; Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King's College London, London, UK. Electronic address: clive.page@kcl.ac.uk.
Lancet Respir Med ; 1(9): 714-27, 2013 Nov.
Article em En | MEDLINE | ID: mdl-24429275
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinonas / Asma / Doença Pulmonar Obstrutiva Crônica / Inibidores da Fosfodiesterase 3 / Inibidores da Fosfodiesterase 4 / Isoquinolinas Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet Respir Med Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Canadá País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinonas / Asma / Doença Pulmonar Obstrutiva Crônica / Inibidores da Fosfodiesterase 3 / Inibidores da Fosfodiesterase 4 / Isoquinolinas Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet Respir Med Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Canadá País de publicação: Reino Unido