IFITM proteins-cellular inhibitors of viral entry.
Curr Opin Virol
; 4: 71-7, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-24480526
Interferon inducible transmembrane (IFITM) proteins are a recently discovered family of cellular anti-viral proteins that restrict the replication of a number of enveloped and non-enveloped viruses. IFITM proteins are located in the plasma membrane and endosomal membranes, the main portals of entry for many viruses. Biochemical and membrane fusion studies suggest IFITM proteins have the ability to inhibit viral entry, possibly by modulating the fluidity of cellular membranes. Here we discuss the IFITM proteins, recent work on their mode of action, and future directions for research.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vírus
/
Interferons
/
Internalização do Vírus
/
Interações Hospedeiro-Patógeno
/
Proteínas de Membrana
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Virol
Ano de publicação:
2014
Tipo de documento:
Article
País de publicação:
Holanda