The efficiency of glutamate uptake differs between neonatal and adult cortical microvascular endothelial cells.
J Cereb Blood Flow Metab
; 34(5): 764-7, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-24517976
ABSTRACT
Glutamate transporters (excitatory amino-acid transporters (EAATs)) are essential for brain homeostasis. While previous studies indicate that the vascular endothelium contributes to glutamate efflux in the adult brain, little information is available regarding glutamate uptake in the immature brain. The present study shows a differential expression pattern of EAATs between cortical microvessels in adults and newborns. In addition, adult cortical endothelial cells take up glutamate more efficiently than neonatal cells. Our findings indicate age-specific changes in extracellular glutamate regulation by brain endothelial cells, suggesting differences in the efficiency of glutamate efflux during an excitotoxic process that, in turn, may contribute to age-specific brain vulnerability.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córtex Cerebelar
/
Ácido Glutâmico
/
Sistema X-AG de Transporte de Aminoácidos
/
Células Endoteliais
Limite:
Animals
Idioma:
En
Revista:
J Cereb Blood Flow Metab
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
França