Nanoscale surface characterization of biphasic calcium phosphate, with comparisons to calcium hydroxyapatite and ß-tricalcium phosphate bioceramics.
J Colloid Interface Sci
; 420: 182-8, 2014 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-24559717
ABSTRACT
OBJECTIVES:
It is our aim to understand the mechanisms that make calcium phosphates, such as bioactive calcium hydroxyapatite (HA), and biphasic calcium (BCP) and ß-tricalcium (ß-TCP) phosphates, desirable for a variety of biological applications, such as the filling of bone defects.METHODS:
Here, we have characterized these materials by X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier-transform infrared (FTIR), time-of-flight secondary ion mass spectroscopy (TOF-SIMS) and laser granulometry.RESULTS:
SEM shows clearly that BCP is a matrix made of macro-organized microstructure, giving insight to the specially chosen composition of the BCP that offers both an adequate scaffold and good porosity for further bone growth. As revealed by laser granulometry, the particles exhibit a homogeneous size distribution, centered at a value somewhat larger than the expected 500 µm. XPS has revealed the presence of adventitious carbon at all sample surfaces, and has shown that Ca/P and O/Ca ratios in the outer layers of all the samples differ significantly from those expected. A peak-by-peak XPS comparison for all samples has revealed that TCP and BCP are distinct from one another in the relative intensities of their oxygen peaks. The PO3(-)/PO2(-) and CaOH+/Ca+ TOF-SIMS intensity ratios were used to distinguish among the samples, and to demonstrate that the OH- fragment, present in all the samples, is not formed during fragmentation but exists at the sample surface, probably as a contaminant.CONCLUSIONS:
This study provides substantial insight into the nanoscale surface properties of BCP, HA and ß-TCP. Further research is required to help identify the effect of surfaces of these bioceramics with proteins and several biological fluids. CLINICAL RELEVANCE The biological performance of implanted synthetic graft bone biomaterials is strongly influenced by their nanosurface characteristics, the structures and properties of the outer layer of the biomaterial.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfatos de Cálcio
/
Cerâmica
/
Durapatita
/
Substitutos Ósseos
/
Hidroxiapatitas
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
J Colloid Interface Sci
Ano de publicação:
2014
Tipo de documento:
Article