Characterization of glioma microcirculation and tissue features using intravoxel incoherent motion magnetic resonance imaging in a rat brain model.
Invest Radiol
; 49(7): 485-90, 2014 Jul.
Article
em En
| MEDLINE
| ID: mdl-24619211
ABSTRACT
PURPOSE:
Our aim was to investigate the pertinence of diffusion and perfusion magnetic resonance imaging (MRI) parameters obtained at 17.2 T in a 9L glioma rat brain tumor model to evaluate tumor tissue characteristics. MATERIALS ANDMETHODS:
The local animal ethics advisory committee approved this study. 9L glioma cells were injected intracerebrally to 14 Fischer rats. The animals were imaged at 7 or 12 days after implantation on a 17.2-T MRI scanner, using 72 different b values (2-3025 s/mm(2)). The signal attenuation, S/So, was fitted using a kurtosis diffusion model (ADCo and K) and a biexponential diffusion model (fractions ffast and fslow and diffusion coefficients Dfast and Dslow) using b values greater than 300 s/mm(2). To bridge the 2 models, an average diffusion coefficientRESULTS:
Intravoxel incoherent motion maps clearly highlighted tumor areas as generally heterogeneous, as confirmed by histology. For diffusion parameters, ADCo andCONCLUSION:
Quantitative non-Gaussian diffusion and perfusion MRI can provide valuable information on microvasculature and tissue structure to improve characterization of brain tumors.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
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Angiografia por Ressonância Magnética
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Glioma
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Microcirculação
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Neovascularização Patológica
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Aspecto:
Ethics
Limite:
Animals
Idioma:
En
Revista:
Invest Radiol
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Japão