Cucurbitane-type triterpenoids from the stems and leaves of Momordica charantia.
Fitoterapia
; 95: 75-82, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-24631764
ABSTRACT
Six new cucurbitane-type triterpenoids, karavilagenin F (1), karavilosides XII and XIII (2, 3), momordicines VI, VII, and VIII (4, 5 and 6), along with four known ones, 5ß,19-epoxy-25-methoxycucurbita-6,23-diene-3ß,19-diol (7), 5ß,19-epoxycucurbita-6, 23-diene-3ß,19,25-triol (8), kuguacin R (9), and (19R,23E)-5ß,19-epoxy-19-methoxycucurbita-6,23,25-trien-3ß-ol (10), were isolated from the stems and leaves of Momordica charantia L. Their chemical structures were elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, COSY, and ROESY), MS experiments, and CD spectrum. Compound 6 showed weak cytotoxicity against five human cancer cells lines with IC50 values of 14.3-20.5µmol/L.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triterpenos
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Extratos Vegetais
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Momordica charantia
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Glicosídeos
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Antineoplásicos Fitogênicos
Limite:
Humans
Idioma:
En
Revista:
Fitoterapia
Ano de publicação:
2014
Tipo de documento:
Article