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Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk.
Holmen, Oddgeir L; Zhang, He; Fan, Yanbo; Hovelson, Daniel H; Schmidt, Ellen M; Zhou, Wei; Guo, Yanhong; Zhang, Ji; Langhammer, Arnulf; Løchen, Maja-Lisa; Ganesh, Santhi K; Vatten, Lars; Skorpen, Frank; Dalen, Håvard; Zhang, Jifeng; Pennathur, Subramaniam; Chen, Jin; Platou, Carl; Mathiesen, Ellisiv B; Wilsgaard, Tom; Njølstad, Inger; Boehnke, Michael; Chen, Y Eugene; Abecasis, Gonçalo R; Hveem, Kristian; Willer, Cristen J.
Afiliação
  • Holmen OL; 1] HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway. [2] St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. [3].
  • Zhang H; 1] Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA. [2].
  • Fan Y; 1] Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA. [2].
  • Hovelson DH; 1] Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA. [2] Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
  • Schmidt EM; 1] Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA. [2] Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
  • Zhou W; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Guo Y; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Zhang J; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Langhammer A; HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
  • Løchen ML; Epidemiology of Chronic Diseases Research Group, Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.
  • Ganesh SK; 1] Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA. [2] Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA.
  • Vatten L; Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway.
  • Skorpen F; Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway.
  • Dalen H; 1] Department of Medicine, Levanger Hospital, Nord-Trøndelag Health Trust, Levanger, Norway. [2] Medical Imaging Laboratory for Innovative Future Healthcare, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.
  • Zhang J; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Pennathur S; Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, Michigan, USA.
  • Chen J; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Platou C; Department of Medicine, Levanger Hospital, Nord-Trøndelag Health Trust, Levanger, Norway.
  • Mathiesen EB; 1] Brain and Circulation Research Group, Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway. [2] Brain and Circulation Research Group, University Hospital of North Norway, Tromsø, Norway.
  • Wilsgaard T; Epidemiology of Chronic Diseases Research Group, Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.
  • Njølstad I; Epidemiology of Chronic Diseases Research Group, Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.
  • Boehnke M; Department of Biostatistics, Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
  • Chen YE; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Abecasis GR; Department of Biostatistics, Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
  • Hveem K; 1] HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway. [2] Department of Medicine, Levanger Hospital, Nord-Trøndelag Health Trust, Levanger, Norway.
  • Willer CJ; 1] Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA. [2] Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. [3] Department of Human Genetics, University of Michigan, Ann Arbo
Nat Genet ; 46(4): 345-51, 2014 Apr.
Article em En | MEDLINE | ID: mdl-24633158
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Lipídeos / Proteínas de Membrana / Infarto do Miocárdio Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans País/Região como assunto: Europa Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2014 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Lipídeos / Proteínas de Membrana / Infarto do Miocárdio Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans País/Região como assunto: Europa Idioma: En Revista: Nat Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2014 Tipo de documento: Article País de publicação: Estados Unidos