Managing the child with severe primary insulin-like growth factor-1 deficiency (IGFD): IGFD diagnosis and management.
Drugs R D
; 14(1): 25-9, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-24639006
ABSTRACT
Growth failure associated with severe primary insulin-like growth factor 1 (IGF-1) deficiency (SPIGFD), a condition defined as basal IGF-1 standard deviation score (SDS) less than or equal to -3 and height SDS less than or equal to -3 in a child with normal or elevated levels of growth hormone, can be successfully treated with the recombinant human IGF-1 mecasermin. In this review, we describe the most safe and effective way to use mecasermin in the treatment of patients with SPIGFD, including how to initiate dosing, key side effects, and how to monitor treatment. Finally, mention of how to reinitiate therapy is made, given the recent drug shortage with mecasermin.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator de Crescimento Insulin-Like I
/
Transtornos do Crescimento
/
Perda Auditiva Neurossensorial
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Drugs R D
Assunto da revista:
TERAPIA POR MEDICAMENTOS
Ano de publicação:
2014
Tipo de documento:
Article