Auditory event-related potentials (P300) and mesial temporal sclerosis in temporal lobe epilepsy patients.
Epileptic Disord
; 16(1): 67-73, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-24691299
ABSTRACT
AIMS:
To investigate the role of centrally recorded P300 in patients suffering from mesial temporal sclerosis-temporal lobe epilepsy (MTS-TLE).METHODS:
Sixteen patients (3 men and 13 women; median age 32.5 years old) suffering from TLE with MTS and 43 healthy controls (12 men and 31 women; median age 35 years old) participated in the study. P300 was elicited using an auditory two-stimulus oddball paradigm. In order to address the aim of the study, we adopted two statistical approaches; hierarchical linear regression analyses and ROC curves.RESULTS:
After adjusting for age, MTS patients had a mean reduction of P300 amplitude by 6.93 µV and a mean increase of P300 latency by 38.78 ms, compared to controls. Age and MTS-TLE status accounted for 32 and 16% of the variance of latency and amplitude, respectively. Diagnostic analyses to detect MTS-TLE status revealed a sensitivity and specificity of 88 and 65% for amplitude and 81 and 70% for latency, respectively. No association between duration of disease and P300 characteristics were found.CONCLUSIONS:
This study, along with other studies, contributes to our understanding and clinical significance of centrally recorded P300s in MTS-TLE patients. Future studies should focus on the association of these P300s with cognition in such patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esclerose
/
Lobo Temporal
/
Epilepsia do Lobo Temporal
/
Potenciais Evocados Auditivos
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Epileptic Disord
Assunto da revista:
CEREBRO
/
NEUROLOGIA
Ano de publicação:
2014
Tipo de documento:
Article