Differences in MCT1 A1470T polymorphism prevalence between runners and swimmers.
Scand J Med Sci Sports
; 25(3): 365-71, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-24708341
ABSTRACT
Skeletal muscle is the major producer and user of lactate in the body. Therefore, transport of lactate across cells' membrane is of considerable importance. Lactate transport is mediated by proton-linked monocarboxylate transporter (MCT1). The A1470T polymorphism (rs1049434) in MCT1 gene influences lactate transport, with T allele associated with reduction of lactate transport rate and elevation in blood lactate levels. The aim of the current study was to compare allelic and genotype frequencies of MCT1 A1470T polymorphism among Israeli track-and-field athletes, swimmers, and non-athletes. Genomic DNA was extracted from 173 track-and-field athletes (age 17-50), 80 swimmers (age 16-49), and 128 non-athletes (age 19-29). Track-and-field athletes were assigned to three subgroups long-distance runners, middle-distance runners, and power event athletes. Swimmers were assigned to two subgroups long-distance swimmers and short-distance swimmers. Genotyping was performed using polymerase chain reaction. T-allele frequency was significantly higher among long-distance swimmers (45%) compared with long- and middle-distance runners (27% and 30%, respectively; P < 0.01). In addition, T-allele frequency was significantly higher among short-distance swimmers (40%) compared with power event athletes (25%, P < 0.01). Overall, T-allele frequency was significantly higher among swimmers (42%) compared with runners (27%, P < 0.001). More research is needed to clarify whether this polymorphism displays advantage for swimming performance.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Corrida
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Natação
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Transportadores de Ácidos Monocarboxílicos
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Simportadores
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Atletas
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Frequência do Gene
Tipo de estudo:
Observational_studies
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Prevalence_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Scand J Med Sci Sports
Assunto da revista:
MEDICINA ESPORTIVA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Israel