New norclerodane diterpenoids from the tubers of Dioscorea bulbifera.
Chem Pharm Bull (Tokyo)
; 62(7): 719-24, 2014.
Article
em En
| MEDLINE
| ID: mdl-24740003
ABSTRACT
Phytochemical investigations of the tubers of Dioscorea bulbifera L. resulted in the isolation of nine norclerodane diterpenoids, including two new compounds, diosbulbins N (1) and P (3), a new naturally occurring compound, diosbulbin O (2), and six known ones, diosbulbins A-D, F and G (4-9). Their structures were established by spectroscopic and chemical methods. The absolute stereochemistry of 1 was determined by a modified Mosher's method, and the absolute configuration of 2 was determined by a single-crystal X-ray diffraction analysis with CuKα irradiation. Compounds 1-3 were evaluated for in vitro cytotoxicity against five human cancer cell lines.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dioscorea
/
Diterpenos Clerodânicos
Idioma:
En
Revista:
Chem Pharm Bull (Tokyo)
Ano de publicação:
2014
Tipo de documento:
Article