[Changes of epidermal growth factor level in blood serum, saliva and gastric juice in children with duodenal ulcer].
Vestn Ross Akad Med Nauk
; (12): 36-40, 2013.
Article
em Ru
| MEDLINE
| ID: mdl-24741940
AIM: The aim of our study is to investigate EGF content in biological mediums in children with duodenum ulcer depending on phase of the disease and different variants of its course. MATERIALS AND METHODS: The present study was performed in Federal State Establishment "Nizhniy Novgorod Research Institute of Children Gastroenterology", Nizhniy Novgorod, Russia. 92 children, between the ages of 8 to 17, with duodenum ulcer were under observation. Endoscopy was performed by Pentax endoscope (FG-24V). EGF detection was performed in blood serum, gastric juice and saliva by ELISA method with Human EGF Kit, "Invitrogen", USA. RESULTS: The peculiarities of EGF level changes in human biological mediums, depending on phase of the disease. The highest EGF level was detected with acute peptic ulcer in the presence of ulcerous defects. EGF level increasing was marked out in the remission phaseas ulcerous defects healing, and it didn't reach normal values in gastric juice. EGF content changes in biological mediums were revealed with different variants of duodenum ulcer clinical course in children. The lowest EGF level was marked out in blood, saliva and gastric juice with unfavorable course of the disease (frequent relapses, cicatricial-ulcerous strains formation), which can serve as a prognostic factor.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saliva
/
Soro
/
Úlcera Duodenal
/
Fator de Crescimento Epidérmico
/
Suco Gástrico
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Aspecto:
Patient_preference
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
Ru
Revista:
Vestn Ross Akad Med Nauk
Assunto da revista:
MEDICINA
Ano de publicação:
2013
Tipo de documento:
Article
País de publicação:
Federação Russa