Your browser doesn't support javascript.
loading
Serum proteomic analysis reveals high frequency of haptoglobin deficiency and elevated thyroxine level in heroin addicts.
Zhou, Bing-Ying; Yan, Shi-Yan; Shi, Wan-Lu; Qu, Zhi; Zhao, Xin; Liu, Zhi-Min; Pu, Xiao-Ping.
Afiliação
  • Zhou BY; National Key Research Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, People's Republic of China; Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing, People's Republic of China.
  • Yan SY; National Institute of Drug Dependence, Peking University, Beijing, People's Republic of China.
  • Shi WL; National Key Research Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, People's Republic of China; Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing, People's Republic of China.
  • Qu Z; National Institute of Drug Dependence, Peking University, Beijing, People's Republic of China.
  • Zhao X; National Key Research Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, People's Republic of China; Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing, People's Republic of China.
  • Liu ZM; National Institute of Drug Dependence, Peking University, Beijing, People's Republic of China.
  • Pu XP; National Key Research Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, People's Republic of China; Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing, People's Republic of China.
PLoS One ; 9(4): e95345, 2014.
Article em En | MEDLINE | ID: mdl-24743330
Heroin addiction is a chronic, complex disease, often accompanied by other concomitant disorders, which may encumber effective prevention and treatment. To explore the differences in expression profiles of serum proteins in control and heroin addicts, we used two-dimensional electrophoresis coupled to MALDI-TOF/TOF, and identified 4 proteins of interest. Following validation of the increase in serum transthyretin, we assessed serum levels of thyroid stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4), and observed a robust increase in T4 in heroin addicts compared to controls. In addition, we performed haptoglobin (Hp) phenotyping, and showed that the frequency of Hp0 (serum devoid of haptoglobin) was significantly higher in heroin addicts. Altogether, these findings indicated that: (1) thyroid hormone imbalance is present in heroin addicts; (2) anhaptoglobinemia (Hp0) might a risk factor or a deleterious effect of heroin abuse.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiroxina / Haptoglobinas / Proteômica / Dependência de Heroína Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2014 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiroxina / Haptoglobinas / Proteômica / Dependência de Heroína Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2014 Tipo de documento: Article País de publicação: Estados Unidos