Pyrene induces a reduction in midbrain size and abnormal swimming behavior in early-hatched pufferfish larvae.
Mar Pollut Bull
; 85(2): 479-86, 2014 Aug 30.
Article
em En
| MEDLINE
| ID: mdl-24793779
ABSTRACT
Spills of heavy oil (HO) have an adverse effect on marine life. We have demonstrated previously that exposure to HO by fertilized eggs of the pufferfish (Takifugu rubripes) induces neural disruption and behavioral abnormality in early-hatched larvae. Here, two kinds of polycyclic aromatic hydrocarbons, pyrene and phenanthrene, were selected to examine their toxic effects on larval behavior of another pufferfish species (T. niphobles). Larvae exposed to pyrene or phenanthrene exhibited no abnormalities in morphology. However, those exposed to pyrene but not phenanthrene swam in an uncoordinated manner, although their swimming distance and speed were normal. The optic tectum, a part of the midbrain, of pyrene-exposed larvae did not grow to full size. Thus, these findings are indicated that pyrene might be a contributor to the behavioral and neuro-developmental toxicity, although there is no indication that it is the only compound participating in the toxicity of the heavy oil mixture.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenantrenos
/
Pirenos
/
Natação
/
Comportamento Animal
/
Tetraodontiformes
Limite:
Animals
Idioma:
En
Revista:
Mar Pollut Bull
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Japão