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Bromopyrrole alkaloids isolated from the Patagonian bryozoan Aspidostoma giganteum.
Patiño C, Laura P; Muniain, Claudia; Knott, Maria Elena; Puricelli, Lydia; Palermo, Jorge A.
Afiliação
  • Patiño C LP; UMYMFOR, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires , Ciudad Universitaria, Pabellón 2 (1428), Buenos Aires, Argentina.
J Nat Prod ; 77(5): 1170-8, 2014 May 23.
Article em En | MEDLINE | ID: mdl-24824796
Nine new bromopyrrole alkaloids, aspidostomides A-H and aspidazide A (1-9), were isolated from the Patagonian bryozoan Aspidostoma giganteum. Aspidostomides A-H have dibromotyrosine- or bromotryptophan-derived moieties forming either linear amides or pyrroloketopiperazine-type lactams with a bromopyrrole carboxylic acid as a common structural motif. On the other hand, aspidazide A is a rare asymmetric acyl azide formed by an N-N link of two different pyrroloketopiperazine lactams and is the first isolated compound of this class from marine invertebrates. This work is the first report of secondary metabolites isolated from a bryozoan from the Patagonian region. The structures of compounds 1-9 were elucidated by spectroscopic methods and chemical transformations. One of these compounds, aspidostomide E (5), was moderately active against the 786-O renal carcinoma cell line.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alcaloides / Hidrocarbonetos Bromados Limite: Animals / Humans Idioma: En Revista: J Nat Prod Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alcaloides / Hidrocarbonetos Bromados Limite: Animals / Humans Idioma: En Revista: J Nat Prod Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos