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Protein binding of rifapentine and its 25-desacetyl metabolite in patients with pulmonary tuberculosis.
Egelund, Eric F; Weiner, Marc; Singh, Rajendra P; Prihoda, Thomas J; Gelfond, Jonathon A L; Derendorf, Hartmut; Mac Kenzie, William R; Peloquin, Charles A.
Afiliação
  • Egelund EF; College of Pharmacy, University of Florida, Gainesville, Florida, USA.
  • Weiner M; Departments of Medicine, University of Texas Health Science Center San Antonio and South Texas Veterans Health Care System, San Antonio, Texas, USA weiner@uthscsa.edu.
  • Singh RP; Clinical Pharmacology Modeling and Simulation, GlaxoSmithKline, King of Prussia, Pennsylvania, USA.
  • Prihoda TJ; Department of Pathology, University of Texas Health Science Center, San Antonio, Texas, USA.
  • Gelfond JA; Departments of Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio, Texas, USA.
  • Derendorf H; College of Pharmacy, University of Florida, Gainesville, Florida, USA.
  • Mac Kenzie WR; Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Peloquin CA; College of Pharmacy, University of Florida, Gainesville, Florida, USA.
Antimicrob Agents Chemother ; 58(8): 4904-10, 2014 Aug.
Article em En | MEDLINE | ID: mdl-24841270
ABSTRACT
Rifapentine is highly protein bound in blood, but the free, unbound drug is the microbiologically active fraction. In this exploratory study, we characterized the free plasma fraction of rifapentine in 41 patients with tuberculosis. We found a lower total rifapentine concentration but significantly higher free rifapentine levels in African patients of black race compared to non-Africans. These data support larger pharmacokinetic/pharmacodynamic studies to confirm these findings and assess free rifapentine in relation to microbiological and clinical outcomes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rifampina / Tuberculose Pulmonar / Proteínas Sanguíneas / Antibióticos Antituberculose Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rifampina / Tuberculose Pulmonar / Proteínas Sanguíneas / Antibióticos Antituberculose Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos