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Through diffusion tensor magnetic resonance imaging to evaluate the original properties of neural pathways of patients with partial seizures and secondary generalization by individual anatomic reference atlas.
Peng, Syu-Jyun; Harnod, Tomor; Tsai, Jang-Zern; Huang, Chien-Chun; Ker, Ming-Dou; Chiou, Jun-Chern; Chiueh, Herming; Wu, Chung-Yu; Hsin, Yue-Loong.
Afiliação
  • Peng SJ; Department of Electrical Engineering, National Central University, Jhongli, Taoyuan 32001, Taiwan.
  • Harnod T; Epilepsy Center, Buddhist Tzu Chi General Hospital, Hualian, Hualian 97002, Taiwan.
  • Tsai JZ; Department of Electrical Engineering, National Central University, Jhongli, Taoyuan 32001, Taiwan.
  • Huang CC; Biomedical Electronics Translational Research Center, National Chiao Tung University, Hsinchu 30010, Taiwan.
  • Ker MD; Biomedical Electronics Translational Research Center, National Chiao Tung University, Hsinchu 30010, Taiwan.
  • Chiou JC; Biomedical Electronics Translational Research Center, National Chiao Tung University, Hsinchu 30010, Taiwan.
  • Chiueh H; Biomedical Electronics Translational Research Center, National Chiao Tung University, Hsinchu 30010, Taiwan.
  • Wu CY; Biomedical Electronics Translational Research Center, National Chiao Tung University, Hsinchu 30010, Taiwan.
  • Hsin YL; Epilepsy Center, Buddhist Tzu Chi General Hospital, Hualian, Hualian 97002, Taiwan ; Biomedical Electronics Translational Research Center, National Chiao Tung University, Hsinchu 30010, Taiwan ; Department of Neurology, Chung Shan Medical University and Chung Shan Medical University Hospital, Taichu
Biomed Res Int ; 2014: 419376, 2014.
Article em En | MEDLINE | ID: mdl-24883310
To investigate white matter (WM) abnormalities in neocortical epilepsy, we extract supratentorial WM parameters from raw tensor magnetic resonance images (MRI) with automated region-of-interest (ROI) registrations. Sixteen patients having neocortical seizures with secondarily generalised convulsions and 16 age-matched normal subjects were imaged with high-resolution and diffusion tensor MRIs. Automated demarcation of supratentorial fibers was accomplished with personalized fiber-labeled atlases. From the individual atlases, we observed significant elevation of mean diffusivity (MD) in fornix (cres)/stria terminalis (FX/ST) and sagittal stratum (SS) and a significant difference in fractional anisotropy (FA) among FX/ST, SS, posterior limb of the internal capsule (PLIC), and posterior thalamic radiation (PTR). For patients with early-onset epilepsy, the diffusivities of the SS and the retrolenticular part of the internal capsule were significantly elevated, and the anisotropies of the FX/ST and SS were significantly decreased. In the drug-resistant subgroup, the MDs of SS and PTR and the FAs of SS and PLIC were significantly different. Onset age was positively correlated with increases in FAs of the genu of the corpus callosum. Patients with neocortical seizures and secondary generalisation had microstructural anomalies in WM. The changes in WM are relevant to early onset, progression, and severity of epilepsy.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Convulsões / Imagem de Difusão por Ressonância Magnética / Epilepsia / Vias Neurais Tipo de estudo: Diagnostic_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Biomed Res Int Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Taiwan País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Convulsões / Imagem de Difusão por Ressonância Magnética / Epilepsia / Vias Neurais Tipo de estudo: Diagnostic_studies Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Biomed Res Int Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Taiwan País de publicação: Estados Unidos