Performance of a 6²Zn/6²Cu microgenerator in kit-based synthesis and delivery of [6²Cu]Cu-ETS for PET perfusion imaging.
Appl Radiat Isot
; 91: 38-43, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-24886964
ABSTRACT
The performance of a commercially produced (62)Zn/(62)Cu microgenerator system, and an associated kit-based radiopharmaceutical synthesis method, was evaluated for clinical site production of [(62)Cu]Cu-ETS (ethylglyoxal bis(thiosemicarbazonato)copper(II)), an investigational agent for PET perfusion imaging. Using 37 generators, containing 1.84±0.23 GBq (62)Zn at 900 AM on the day of clinical use, a total of 45 patient doses of [(62)Cu]Cu-ETS (672±172 MBq) were delivered without difficulty. (62)Cu elution yields were high (approximately 90%), accompanied by extremely low (62)Zn breakthrough (<0.001%). Radiopharmaceutical preparation, from the start-of-elution to time-of-injection, consumed less than five minutes. The (62)Zn/(62)Cu microgenerator was a dependable source of short-lived positron-emitting (62)Cu, and the kit-based synthesis proved to be rapid, robust, and highly reliable for "on-demand" delivery of [(62)Cu]Cu-ETS for PET perfusion imaging.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Geradores de Radionuclídeos
/
Tiossemicarbazonas
/
Radioisótopos de Zinco
/
Radioisótopos de Cobre
/
Compostos Radiofarmacêuticos
/
Imagem de Perfusão
Limite:
Humans
Idioma:
En
Revista:
Appl Radiat Isot
Assunto da revista:
MEDICINA NUCLEAR
/
SAUDE AMBIENTAL
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos