Slow and rapid electrical pulses in the caval vein at pain-evoked leg contraction in the rat.

ABSTRACT

Previous in vivo experiments in rats have shown that pulsed nerve stimulations of 20-50 mV require "external" electrical communication over vessels. This indicates that potential differences also should occur in associated vessels, at physiologic muscle contractions. Pinching toes of the hind leg of anaesthetized rats in the present study caused the animals to spontaneously pull the leg. This resulted in electric potential differences over two intracaval electrodes, as well as high frequency spikes. The slow potential pulses and high frequency spikes could be recorded dominantly in the vena cava compared with the extravascular tissue fluid. The electrical prerequisites and the previous experiments support the view that the vascular-interstitial fluid represents an "external" low resistant communication route of a closed circuit over the nerve cell bodies, the axons and the muscle fibers. A closed electrical circuit evidently increases our possibilities for explaining various structural and chemical events of the synaptic membranes.